Holmes is an ARC Laureate Fellow, former Premier’s Fellow and Head of the Centre for Computational and Systems Medicine at Murdoch University. Her main research area focuses on applying metabolic profiling and computational modelling of biofluids and tissues to understand pathological and physiological processes. She has applied the technology in several clinical and biomedical areas including cardiovascular, neurodegenerative and infectious diseases and has authored over 500 papers in metabolic profiling. Her current research involves the development of metabolic profiling capacity in Western Australia and its application to both population and precision medicine / nutrition, with a focus on healthy aging.